Specifications
Species Reactivity
Mouse; Human
Immunogen
A synthetic peptide corresponding to residues near the C terminus of human ALDH7A1
Applications
Application Notes
ICC/IF: 1/100 - 1/250; WB: 1/50000 - 1/100000; IP: 1/30.
Target
Alternative Names
ALDH7A1; aldehyde dehydrogenase 7 family, member A1; ATQ1; alpha-aminoadipic semialdehyde dehydrogenase; 26g turgor protein homolog; alpha AASA dehydrogenase; alpha aminoadipic semialdehyde dehydrogenase; antiquitin 1; delta1 piperideine 6 carboxylate deh
Product Background
Antigen Description
ALDH7A1 is an evolutionarily conserved protein believed to play a role in the regulation of cellular turgor. Based on sequence analysis, this protein is classified as a member of the aldehyde dehydrogenase superfamily. Analysis of the amount of mRNA in various rat and human tissues indicates that the largest amounts are found in rat kidney and liver and in cultured human hepatoma cells. Only minimal amounts were detected in human peripheral blood leukocytes, rat lung, or cultured human fibroblasts. The plant homolog of ATQ1 is thought to be involved in regulating turgor pressure, a function that also would be essential for cells of the mammalian cochlea. Northern blots of 13 human fetal tissues show antiquitin to be highly expressed in cochlea, ovary, eye, heart, and kidney.
Pathway
Arginine and proline metabolism, organism-specific biosystem; Arginine and proline metabolism, conserved biosystem; Ascorbate and aldarate metabolism, organism-specific biosystem; Ascorbate and aldarate metabolism, conserved biosystem; Fatty acid metabolism, organism-specific biosystem; Fatty acid metabolism, conserved biosystem; GABA biosynthesis, eukaryotes, putrescine =>
Citations
Publication ()
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COA
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