Anti-ALDH2 polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant fragment corresponding to a region within amino acids 151 and 517 of ALDH2 (Uniprot ID#P05091)

Conjugate

Application Notes

ELISA, Pr*, ICC/IF, IHC-P, WB
We recommend the following for sandwich ELISA (Capture - Detection):
DPABY-709 - DPABY-735

Alternative Names

ALDH2; aldehyde dehydrogenase 2 family (mitochondrial); ALDM; ALDHI; ALDH-E2; aldehyde dehydrogenase, mitochondrial; ALDH class 2; liver mitochondrial ALDH; acetaldehyde dehydrogenase 2; nucleus-encoded mitochondrial aldehyde dehydrogenase 2;

Entrez Gene ID

UniProt ID

Antigen Description

This protein belongs to the aldehyde dehydrogenase family of proteins. Aldehyde dehydrogenase is the second enzyme of the major oxidative pathway of alcohol metabolism. Two major liver isoforms of this enzyme, cytosolic and mitochondrial, can be distinguished by their electrophoretic mobilities, kinetic properties, and subcellular localizations. Most Caucasians have two major isozymes, while approximately 50% of Orientals have only the cytosolic isozyme, missing the mitochondrial isozyme. A remarkably higher frequency of acute alcohol intoxication among Orientals than among Caucasians could be related to the absence of the mitochondrial isozyme. This gene encodes a mitochondrial isoform, which has a low Km for acetaldehydes, and is localized in mitochondrial matrix. [provided by RefSeq]

Pathway

Arginine and proline metabolism; Ascorbate and aldarate metabolism; Biological oxidations; Ethanol oxidation; Fatty Acid Omega Oxidation; Fatty acid degradation; GABA biosynthesis, eukaryotes, putrescine => GABA; Glycerolipid metabolism;