Anti-ALDH18A1 (aa 775-784) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide: C-SEHGSLKYLH, corresponding to C terminal amino acids 775-784 of Human P5CS (NP_002851.2).

Conjugate

Application Notes

WB: 1 - 3μg/ml;

Alternative Names

ALDH18A1; aldehyde dehydrogenase 18 family, member A1; GSAS; P5CS; PYCS; ARCL3A; delta-1-pyrroline-5-carboxylate synthase; delta1-pyrroline-5-carboxlate synthetase; aldehyde dehydrogenase family 18 member A1; delta-1-pyrroline-5-carboxylate synthetase; py

Entrez Gene ID

UniProt ID

Antigen Description

This gene is a member of the aldehyde dehydrogenase family and encodes a bifunctional ATP- and NADPH-dependent mitochondrial enzyme with both gamma-glutamyl kinase and gamma-glutamyl phosphate reductase activities. The encoded protein catalyzes the reduction of glutamate to delta1-pyrroline-5-carboxylate, a critical step in the de novo biosynthesis of proline, ornithine and arginine. Mutations in this gene lead to hyperammonemia, hypoornithinemia, hypocitrullinemia, hypoargininemia and hypoprolinemia and may be associated with neurodegeneration, cataracts and connective tissue diseases. Alternatively spliced transcript variants, encoding different isoforms, have been described for this gene.

Pathway

Amino acid synthesis and interconversion (transamination); Arginine and proline metabolism; Biosynthesis of amino acids; Metabolism of amino acids and derivatives