Anti-AKR1C3 (aa 261-323) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Synthetic peptide, corresponding to a region within C terminal amino acids 261-323 of Human AKR1C3.

Conjugate

Application Notes

WB: 1/500 - 1/3000; IHC-P: 1/100 - 1/1000; ICC/IF: 1/100 - 1/1000.

Alternative Names

AKR1C3; aldo-keto reductase family 1, member C3 (3-alpha hydroxysteroid dehydrogenase, type II); HSD17B5, hydroxysteroid (17 beta) dehydrogenase 5; aldo-keto reductase family 1 member C3; DDX; dihydrodiol dehydrogenase X; HAKRB; KIAA0119; PGFS; prostaglan

Entrez Gene ID

UniProt ID

Antigen Description

Catalyzes the conversion of aldehydes and ketones to alcohols. Catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2. Functions as a bi-directional 3-alpha-, 17-beta- and 20-alpha HSD. Can interconvert active androgens, estrogens and progestins with their cognate inactive metabolites. Preferentially transforms androstenedione (4-dione) to testosterone.

Pathway

Arachidonic acid metabolism; Metabolism of xenobiotics by cytochrome P450; Steroid hormone biosynthesis; androgen biosynthesis;