Specifications
Species Reactivity
Human; Mouse; Pig
Immunogen
Recombinant protein corresponding to human AKR1C2.
Applications
Application Notes
WB (1:250-1:500) & The optimal working dilution should be determined by the end user.
Target
Alternative Names
AKR1C2; aldo-keto reductase family 1, member C2 (dihydrodiol dehydrogenase 2; bile acid binding protein; 3-alpha hydroxysteroid dehydrogenase, type III); DDH2; aldo-keto reductase family 1 member C2; BABP; DD; DD2; HAKRD; MCDR2; DD-2; DD/BABP; 3-alpha-HSD
Product Background
Antigen Description
This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols using NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme binds bile acid with high affinity, and shows minimal 3-alpha-hydroxysteroid dehydrogenase activity. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14.
Pathway
Metabolism of xenobiotics by cytochrome P45, organism-specific biosystem; Metabolism of xenobiotics by cytochrome P45, conserved biosystem; Steroid hormone biosynthesis, organism-specific biosystem; Steroid hormone biosynthesis, conserved biosystem.
Citations
Publication ()
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COA
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