Anti-AKR1A1 (full length) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Rat; Human

Immunogen

Recombinant full length protein corresponding to Human AKR1A1 aa 1-325.Sequence: MAASCVLLHTGQKMPLIGLGTWKSEPGQVKAAVKYALSVGYRHIDCAAIY GNEPEIGEALKEDVGPGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLA DLQLEYLDLYLMHWPYAFERGDNPFPKNADGTICYDSTHYKETWKALEAL VAKGLVQALGLSNFNSRQIDD

Conjugate

Application Notes

IHC-P: 1/50 - 1/200; WB: 1/500 - 1/2000.

Alternative Names

AKR1A1; aldo-keto reductase family 1, member A1 (aldehyde reductase); alcohol dehydrogenase [NADP(+)]; ALR; DD3; dihydrodiol dehydrogenase 3; aldehyde reductase; alcohol dehydrogenase; aldo-keto reductase family 1 member A1; ARM; ALDR1; MGC1380; MGC12529;

Entrez Gene ID

UniProt ID

Antigen Description

Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN).

Pathway

Glycerolipid metabolism; Glycolysis / Gluconeogenesis; Metabolic pathways; tryptophan degradation X (mammalian, via tryptamine);