Anti-TXNDC12 monoclonal antibody (DCABH-299)

Mouse anti-Human TXNDC12 monoclonal antibody for IHC-P, ELISA, FC, IP, WB, ICC/IF Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
8G8BC21
Species Reactivity
Human
Immunogen
Human heart mitochondria.
Conjugate
Unconjugated

Applications


Application Notes
IHC-P: 10 μg/ml; In-Cell Flow Cyt: 1 μg/ml; WB: 2 - 5 μg/ml; ICC/IF: 5 - 10 μg/ml.
*Suggested working dilutions are given as a guide only. It is recommended that the user titrates the product for use in their own experiment using appropriate negative and positive controls.

Target


Alternative Names
TXNDC12; thioredoxin domain containing 12 (endoplasmic reticulum); thioredoxin domain-containing protein 12; AGR1; anterior gradient homolog 1 (Xenopus laevis); endoplasmic reticulum thioredoxin superfamily member
Entrez Gene ID
UniProt ID

Product Background


Gene summary
TXNDC12 (Thioredoxin Domain Containing 12) is a Protein Coding gene. Among its related pathways are Glutathione metabolism. GO annotations related to this gene include protein-disulfide reductase (glutathione) activity. An important paralog of this gene is AGR3. This gene encodes a member of the thioredoxin superfamily. Members of this family are characterized by a conserved active motif called the thioredoxin fold that catalyzes disulfide bond formation and isomerization. This protein localizes to the endoplasmic reticulum and has a single atypical active motif. The encoded protein is mainly involved in catalyzing native disulfide bond formation and displays activity similar to protein-disulfide isomerases. This protein may play a role in defense against endoplasmic reticulum stress. Alternate splicing results in both coding and non-coding variants.
Antigen Description
Probable oxidoreductase that has a dual role in controlling cellular life and death; during apoptosis, it is translocated from the mitochondria to the nucleus to function as a proapoptotic factor in a caspase-independent pathway, while in normal mitochondria, it functions as an antiapoptotic factor via its oxidoreductase activity. The soluble form (AIFsol) found in the nucleus induces parthanatos i. e. , caspase-independent fragmentation of chromosomal DNA. Interacts with EIF3G,and thereby inhibits the EIF3 machinery and protein synthesis, and activates casapse-7 to amplify apoptosis. Plays a critical role in caspase-independent, pyknotic cell death in hydrogen peroxide-exposed cells. Binds to DNA in a sequence-independent manner. Possesses significant protein thiol-disulfide oxidase activity. Thioredoxin domain-containing protein 12 is a protein that in humans is encoded by the TXNDC12 gene. 0The function about TXNDC12 antigen include oxidoreductase activity; protein-disulfide reductase (glutathione) activity.
Pathway
Glutathione metabolism, organism-specific biosystem; Glutathione metabolism, conserved biosystem; glutathione redox reactions II, organism-specific biosystem.

Citations


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References


Steibel, JP; Bates, RO; et al. Genome-Wide Linkage Analysis of Global Gene Expression in Loin Muscle Tissue Identifies Candidate Genes in Pigs. PLOS ONE 6:-(2011).
Galvan, A; Frullanti, E; et al. Gene expression signature of non-involved lung tissue associated with survival in lung adenocarcinoma patients. CARCINOGENESIS 34:2767-2773(2013).

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