Rabbit Anti-Human AGO1 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Synthetic peptide corresponding to a region derived from internal residues of human argonaute RISC catalytic component 1

Conjugate

Application Notes

IHC: 1:50-1:200

General Notes

This product (Catalog No. DPABH-26202) is a rabbit-derived IgG polyclonal antibody raised against human AGO1. This antibody exhibits cross-reactivity with AGO1 from mouse. It has been affinity purified by protein A. This gene encodes a member of the argonaute family of proteins, which associate with small RNAs and have important roles in RNA interference (RNAi) and RNA silencing. This protein binds to microRNAs (miRNAs) or small interfering RNAs (siRNAs) and represses translation of mRNAs that are complementary to them. It is also involved in transcriptional gene silencing (TGS) of promoter regions that are complementary to bound short antigene RNAs (agRNAs), as well as in the degradation of miRNA-bound mRNA targets. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. A recent study showed this gene to be an authentic stop codon readthrough target, and that its mRNA could give rise to an additional C-terminally extended isoform by use of an alternative in-frame translation termination codon.
DPABH-26202 is suitable for use in IHC (1:50–1:200) application.
DPABH-26202 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

Q99; EIF2C; EIF2C1; GERP95

Entrez Gene ID

UniProt ID