Recombinant human AFAP1L1 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 1-117 aa of BC125093
Conjugate
Unconjugated
Applications
Application Notes
WB: 1:500-1:1000
General Notes
This product (Catalog No. DPABH-02277) is a rabbit-derived polyclonal antibody raised against human AFAP1L1, targeting the amino acid region 1–117 of the protein. This antibody exhibits cross-reactivity with Human AFAP1L1 from monkey. It has been affinity purified by Protein A. Actin Filament-Associated Protein of 110 kDa (AFAP-110/AFAP1) is an adaptor protein with multiple protein binding motifs that is known to function as both an actin binding protein and a cSrc activating protein. A homology search of AFAP1 recently identified AFAP1L1 which has a similar sequence, domain structure and cellular localization. AFAP1L1 is highly expressed in human breast, colon and brain tissue. AFAP1L1 interacts with cortactin and involves the invadosomes formation. AFAP1L1 as a prognostic marker has a role in the progression of spindle cell sarcomas. DPABH-02277 is suitable for use in Western blot (WB) (1:500–1:1,000) application. DPABH-02277 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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