Anti-ADRA2B monoclonal antibody, clone FQS0734

Antibody Isotype

IgG

Clone

FQS0734

Species Reactivity

Mouse; Rat; Human

Immunogen

Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) (N terminal)

Conjugate

Application Notes

WB: 1/10000 - 1/50000; Flow Cyt: 1/10 - 1/100; IP: 1/10 - 1/100;

Alternative Names

ADRA2B; adrenergic, alpha-2B-, receptor; ADRA2L1, ADRA2RL1; alpha-2B adrenergic receptor; ADRARL1; alpha-2BAR; alpha-2B adrenoceptor; alpha-2B adrenoreceptor; G-protein coupled receptor; adrenergic receptor alpha 2B; alpha-2B-adrenergic receptor; alpha-2-

Entrez Gene ID

UniProt ID

Antigen Description

Alpha-2-adrenergic receptors are members of the G protein-coupled receptor superfamily. They include 3 highly homologous subtypes: alpha2A, alpha2B, and alpha2C. These receptors have a critical role in regulating neurotransmitter release from sympathetic nerves and from adrenergic neurons in the central nervous system. Alpha 2B adrenergic receptor subtype was observed to associate with eIF-2B, a guanine nucleotide exchange protein that functions in regulation of translation. A polymorphic variant of the alpha2B subtype, which lacks 3 glutamic acids from a glutamic acid repeat element, was identified to have decreased G protein-coupled receptor kinase-mediated phosphorylation and desensitization; this polymorphic form is also associated with reduced basal metabolic rate in obese subjects and may therefore contribute to the pathogenesis of obesity. Alpha 2B adrenergic receptor gene contains no introns in either its coding or untranslated sequences.

Pathway

Adrenaline signalling through Alpha-2 adrenergic receptor, organism-specific biosystem; Adrenoceptors, organism-specific biosystem; Amine ligand-binding receptors, organism-specific biosystem; Class A/1 (Rhodopsin-like receptors), organism-specific biosystem; G alpha (i) signalling events, organism-specific biosystem; G alpha (z) signalling events, organism-specific biosystem; GPCR downstream signaling, organism-specific biosystem.