Alpha-1-adrenergic receptors (alpha-1-ARs) are members of the G protein-coupled receptor superfamily. They activate mitogenic responses and regulate growth and proliferation of many cells. There are 3 alpha-1-AR subtypes: alpha-1A, -1B and -1D, all of which signal through the Gq/11 family of G-proteins and different subtypes show different patterns of activation. This gene encodes alpha-1D-adrenergic receptor. Similar to alpha-1B-adrenergic receptor gene, this gene comprises 2 exons and a single intron that interrupts the coding region.
Pathway
Adrenergic signaling in cardiomyocytes; Adrenoceptors; Amine ligand-binding receptors; Calcium Regulation in the Cardiac Cell; Calcium signaling pathway; Class A/1 (Rhodopsin-like receptors); G alpha (12/13) signalling events; G alpha (q) signalling events; GPCR downstream signaling; GPCR ligand binding; GPCRs, Class A Rhodopsin-like;
Citations
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