Anti-ADPRHL2 monoclonal antibody (DCABH-10443) Made to order

Rabbit anti-Human ADPRHL2 monoclonal antibody for WB, ELISA

View other ADPRHL2 antibodies

Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
A synthetic peptide of human ADPRHL2 is used for rabbit immunization.
Conjugate
Unconjugated

Target


Alternative Names
ADPRHL2; ADP-ribosylhydrolase like 2; poly(ADP-ribose) glycohydrolase ARH3; ARH3; FLJ20446; ADP-ribosylhydrolase 3
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ADPRHL2 (ADP-Ribosylhydrolase Like 2) is a Protein Coding gene. GO annotations related to this gene include poly(ADP-ribose) glycohydrolase activity. This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasm.
Antigen Description
This gene encodes a member of the ADP-ribosylglycohydrolase family. The encoded enzyme catalyzes the removal of ADP-ribose from ADP-ribosylated proteins. This enzyme localizes to the mitochondria, in addition to the nucleus and cytoplasmPoly(ADP-ribose) synthesized after DNA damage is only present transiently and is rapidly degraded by poly(ADP-ribose) glycohydrolase. Poly(ADP-ribose) metabolism may be required for maintenance of the normal function of neuronal cells. Generates ADP-ribose from poly-(ADP-ribose), but does not hydrolyze ADP-ribose-arginine, -cysteine, -diphthamide, or -asparagine bonds. Due to catalytic inactivity of PARG mitochondrial isoforms, ARH3 is the only PAR hydrolyzing enzyme in mitochondria. Poly(ADP-ribose) glycohydrolase ARH3 is an enzyme that in humans is encoded by the ADPRHL2 gene. 0The function about ADPRHL2 antigen include hydrolase activity; metal ion binding; poly(ADP-ribose) glycohydrolase activity.

Citations


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References


Corda, D; Di Girolamo, M; et al. Functional aspects of protein mono-ADP-ribosylation. EMBO JOURNAL 22:1953-1958(2003).
Ono, T; Kasamatsu, A; et al. The 39-kDa poly(ADP-ribose) glycohydrolase ARH3 hydrolyzes O-acetyl-ADP-ribose, a product of the Sir2 family of acetyl-histone deacetylases. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 103:16687-16691(2006).

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