The ADHFE1 gene encodes hydroxyacid-oxoacid transhydrogenase (EC 1.1.99.24), which is responsible for the oxidation of 4-hydroxybutyrate in mammalian tissues (Kardon et al., 2006 [PubMed 16616524]).
Pathway
Interconversion of 2-oxoglutarate and 2-hydroxyglutarate, organism-specific biosystem; Metabolism, organism-specific biosystem; Pyruvate metabolism and Citric Acid (TCA) cycle, organism-specific biosystem; The citric acid (TCA) cycle and respiratory electron transport, organism-specific biosystem;
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