ADCY5 (NP_899200, 1152 a.a. ~ 1261 a.a) partial recombinant protein with GST tag. The sequence is ADFAMKLMDQMKYINEHSFNNFQMKIGLNIGPVVAGVIGARKPQYDIWGNTVNVASRMDS TGVPDRIQVTTDMYQVLAANTYQLECRGVVKVKGKGEMMTYFLNGGPPLS
Conjugate
Unconjugated
Target
Alternative Names
ADCY5; adenylate cyclase 5; AC5; FDFM; adenylate cyclase type 5; adenylyl cyclase 5; adenylate cyclase type V; ATP pyrophosphate-lyase 5;
This gene encodes a member of the membrane-bound adenylyl cyclase enzymes. Adenylyl cyclases mediate G protein-coupled receptor signaling through the synthesis of the second messenger cAMP. Activity of the encoded protein is stimulated by the Gs alpha subunit of G protein-coupled receptors and is inhibited by protein kinase A, calcium and Gi alpha subunits. Single nucleotide polymorphisms in this gene may be associated with low birth weight and type 2 diabetes. Alternatively spliced transcript variants that encode different isoforms have been observed for this gene.
Pathway
Activation of GABAB receptors; Adenylate cyclase inhibitory pathway; Adrenergic signaling in cardiomyocytes; Amphetamine addiction
Citations
Publication ()
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