Specifications
Species Reactivity
Mouse; Human
Immunogen
Synthetic peptide (the amino acid sequence is considered to be commercially sensitive) within Human Centaurin alpha 1 aa 150-250. The exact sequence is proprietary.Database link: O75689
Applications
Application Notes
WB: 1/1000 - 1/20000; ICC/IF: 1/100; IP: 1/20 - 1/40;
Target
Alternative Names
ADAP1; ArfGAP with dual PH domains 1; CENTA1, centaurin, alpha 1; arf-GAP with dual PH domain-containing protein 1; GCS1L; cnt-a1; centaurin-alpha; centaurin-alpha-1; centaurin, alpha 1; putative MAPK-activating protein PM25; CENTA1; p42IP4;
Product Background
Antigen Description
The centaurin alpha 1 protein is a high affinity PtdIns(3,4,5)P3 binding protein enriched in brain. By acting as a GTPase activating protein for ADP ribosylation factor 6 (ARF6), centaurin alpha 1 is able to switch off ARF6 and inhibit its ability to mediate beta 2 adrenoceptor internalization and negatively regulates ARF6 activity by functioning as an in vivo PIP3 dependent ARF6 GAP.
Pathway
Arf6 signaling events, organism-specific biosystem; Class I PI3K signaling events, organism-specific biosystem.
Citations
Publication ()
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COA
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