Anti-ADAMTS2 (aa 1112-1210) polyclonal antibody

Species Reactivity

Human

Immunogen

ADAMTS2 (NP_055059, 1112 a.a. ~ 1210 a.a) partial recombinant protein with GST tag. The sequence is KHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPLNASSTNATEDHPETNAVDEPYKIHGLE DEVQPPNLIPRRPSPYEKTRNQRIQELIDEMRKKEMLGK

Conjugate

Alternative Names

ADAMTS2; ADAM metallopeptidase with thrombospondin type 1 motif, 2; NPI; PNPI; PCINP; PCPNI; PCI-NP; PC I-NP; ADAM-TS2; ADAMTS-2; ADAMTS-3; A disintegrin and metalloproteinase with thrombospondin motifs 2; procollagen I N-proteinase; procollagen N-endopep

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene excises the N-propeptide of type I, type II and type V procollagens. Mutations in this gene cause Ehlers-Danlos syndrome type VIIC, a recessively inherited connective-tissue disorder. Alternative splicing results in multiple transcript variants.

Pathway

Collagen biosynthesis and modifying enzymes; Extracellular matrix organization; O-glycosylation of TSR domain-containing proteins; Post-translational protein modification