General Notes
This product (Catalog No. DPABH-10202) is a rabbit-derived polyclonal antibody raised against human ADAM20, targeting the amino acid region 367–615 of the protein. It has been affinity purified by Protein A. ADAM20 is a human gene located on chromosome 14q24.2 that encodes a membrane-anchored protein belonging to the A Disintegrin and Metalloproteinase (ADAM) family, characterized by its disintegrin and metalloprotease domains structurally related to snake venom disintegrins. This protein, known as disintegrin and metalloproteinase domain-containing protein 20, is primarily expressed in the testis and plays a role in cell-cell and cell-matrix interactions, particularly in processes such as fertilization and sperm-egg fusion. Predicted to possess metalloendopeptidase activity, ADAM20 is involved in proteolysis and male gonad development, with localization to the plasma membrane and sperm head. A rare variant of ADAM20 has been linked to a sperm-egg fusion disorder in a clinical case, highlighting its potential significance in reproductive biology.
DPABH-10202 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-10202 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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