Recombinant human ACTR8 protein; Source: E. coli derived, PGEX-4T; Tag: GST; Domain: 1-329 aa of BC032744
Conjugate
Unconjugated
Applications
Application Notes
WB: 1:500-1:2000
General Notes
This product (Catalog No. DPABH-12388) is a rabbit-derived polyclonal antibody raised against human ACTR8, targeting the amino acid region 1–329 of the protein. It has been affinity purified by Protein A. Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA reoplication and probably DNA repair. Required for the recruitment of INO80 (and probably the INO80 complex) to sites of DNA damage. Strongly prefer nucleosomes and H3-H4 tetramers over H2A-H2B dimers, suggesting it may act as a nucleosome recognition module within the complex. DPABH-12388 is suitable for use in Western blot (WB) (1:500–1:2,000) application. DPABH-12388 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
Target
Alternative Names
Actin related protein 8; ACTR8; ARP8; INO80 complex subunit N; INO80N
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