Anti-ACTL6B polyclonal antibody

Species Reactivity

Human

Immunogen

A synthetic peptide corresponding to human ACTL6A/ACTL6B. The sequence is YEEGGKQCVERKCP

Conjugate

Application Notes

ELISA: 1:64000; WB: 1-3 μg/mL. & The optimal working dilution should be determined by the end user.

Alternative Names

ACTL6B; actin-like 6B; ACTL6; BAF53B; actin-like protein 6B; arpNalpha; hArpN alpha; actin-like 6; BRG1-associated factor 53B; actin-related protein Baf53b; 53 kDa BRG1-associated factor B;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of a family of actin-related proteins (ARPs) which share significant amino acid sequence identity to conventional actins. Both actins and ARPs have an actin fold, which is an ATP-binding cleft, as a common feature. The ARPs are involved in diverse cellular processes, including vesicular transport, spindle orientation, nuclear migration and chromatin remodeling. This gene encodes a subunit of the BAF (BRG1/brm-associated factor) complex in mammals, which is functionally related to SWI/SNF complex in S. cerevisiae and Drosophila; the latter is thought to facilitate transcriptional activation of specific genes by antagonizing chromatin-mediated transcriptional repression. This subunit may be involved in the regulation of genes by structural modulation of their chromatin, specifically in the brain.

Pathway

Prostate Cancer;