Anti-ACTG1 monoclonal antibody, clone 6D6

Antibody Isotype

IgM

Clone

6D6

Species Reactivity

Rabbit

Immunogen

BALB/C mice were injected with purified rabbit striated muscle actin.

Conjugate

Alternative Names

ACTG1; actin, gamma, cytoplasmic 1; actin, cytoplasmic 2; gamma-actin; beta-actin FE-3; E51; Actg; Actl; AL023024;

Entrez Gene ID

UniProt ID

Antigen Description

Cytoplasmic actins, which belong to the microfilament system of cytoskeleton proteins, are some of the most conserved eukaryotic proteins being expressed in mammals and birds. The actin protein consists of six isoforms, varying in their amino acid sequence, but all having the same molecular mass of 42 kDa. The isoforms show more than 90% overall sequence homology, but only 50-60% homology in their 18 N-terminal residues. The N-terminal region appears to be a major antigenic region. There are different alpha isoforms specific for muscle tissues, i.e. skeletal muscle alpha, cardiac muscle alpha, and smooth muscle alpha, respectively.

Pathway

Adherens junction, organism-specific biosystem; Adherens junction, conserved biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), organism-specific biosystem; Arrhythmogenic right ventricular cardiomyopathy (ARVC), conserved biosystem; Bacterial invasion of epithelial cells, organism-specific biosystem; Bacterial invasion of epithelial cells, conserved biosystem; Dilated cardiomyopathy, organism-specific biosystem;