Anti-ACMSD (aa 105-307) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

Recombinant protein fragment containing a sequence corresponding to a region within amino acids 105 and 307 of Human ACMSD.

Conjugate

Application Notes

WB: 1/500 - 1/3000.

Alternative Names

ACMSD; aminocarboxymuconate semialdehyde decarboxylase; 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; picolinate carboxylase;

Entrez Gene ID

UniProt ID

Antigen Description

Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.

Pathway

2-amino-3-carboxymuconate semialdehyde degradation to glutaryl-CoA; Metabolic pathways; Metabolism; Metabolism of amino acids and derivatives; Tryptophan catabolism; Tryptophan metabolism;