Anti-ACKR1 polyclonal antibody (DPAB-L20359)

Rabbit anti-Human ACKR1 (C-terminal) polyclonal antibody for IHC Datasheet

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Specifications


Host Species
Rabbit
Antibody Isotype
IgG
Species Reactivity
Human
Immunogen
DARC antibody was raised against a 16 amino acid peptide from near the carboxy terminus of human DARC.
Conjugate
Unconjugated

Target


Alternative Names
ACKR1; atypical chemokine receptor 1 (Duffy blood group); FY; Dfy; GPD; DARC
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ACKR1 (Atypical Chemokine Receptor 1 (Duffy Blood Group)) is a Protein Coding gene. Diseases associated with ACKR1 include malaria and plasmodium vivax malaria. Among its related pathways are Signaling by GPCR and Peptide ligand-binding receptors. GO annotations related to this gene include G-protein coupled receptor activity and transmembrane signaling receptor activity. The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene.
Antigen Description
The protein encoded by this gene is a glycosylated membrane protein and a non-specific receptor for several chemokines. The encoded protein is the receptor for the human malarial parasites Plasmodium vivax and Plasmodium knowlesi. Polymorphisms in this gene are the basis of the Duffy blood group system. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1, TARC and also for the malaria parasites P. vivax and P. knowlesi. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels. Duffy antigen/chemokine receptor (DARC), also known as Fy glycoprotein (FY) or CD234 (Cluster of Differentiation 234), is a protein that in humans is encoded by the DARC gene. 0The function about ACKR1 antigen include C-C chemokine binding; G-protein coupled receptor activity; receptor activity; transmembrane signaling receptor activity.
Pathway
Class A/1 (Rhodopsin-like receptors); GPCR ligand binding; GPCRs; Malaria; Peptide GPCRs; Peptide ligand-binding receptors; Signal Transduction; Signaling by GPCR.

Citations


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References


Schneider, EH; Fowler, SC; et al. Regulation of Motor Function and Behavior by Atypical Chemokine Receptor 1. BEHAVIOR GENETICS 44:498-515(2014).
Ford, LB; Cerovic, V; et al. Characterization of Conventional and Atypical Receptors for the Chemokine CCL2 on Mouse Leukocytes. JOURNAL OF IMMUNOLOGY 193:400-411(2014).

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