General Notes
This product (Catalog No. DPABH-10311) is a rabbit-derived polyclonal antibody raised against human ABHD2, targeting the amino acid region 40–425 of the protein. This antibody exhibits cross-reactivity with Human ABHD2 from mouse. It has been affinity purified by Protein A. ABHD2, or abhydrolase domain containing 2, is a gene that encodes a serine hydrolase enzyme functioning primarily as an acylglycerol lipase, characterized by an alpha/beta hydrolase fold catalytic domain. This protein hydrolyzes endocannabinoids such as 2-arachidonoylglycerol (2AG) from cell membranes, playing a pivotal role in sperm capacitation by removing 2AG inhibition of the CatSper calcium channel, which is essential for sperm hyperactivation and fertilization. Expressed ubiquitously across human tissues with highest levels in the liver and stomach, ABHD2 is particularly critical in spermatozoa, where it localizes to the plasma membrane and acrosomal vesicle.
DPABH-10311 is suitable for use in ELISA (1:4,000–1:8,000), IHC (1:50–1:100), IF (immunofluorescence) (1:50–1:100), Western blot (WB) (1:1,000–1:4,000) applications.
DPABH-10311 is supplied as a liquid formulation in 0.01M PBS, pH 7.4, 50% Glycerol, 0.05% Proclin 300. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
COA
Publication 
Loading ......
