Anti-ABCC2 (aa 214-313) polyclonal antibody

Species Reactivity

Human

Immunogen

ABCC2 (NP_000383, 214 a.a. ~ 313 a.a) partial recombinant protein with GST tag. The sequence is LKGYKRPLTLEDVWEVDEEMKTKTLVSKFETHMKRELQKARRALQRRQEKSSQQNSGARL PGLNKNQSQSQDALVLEDVEKKKKKSGTKKDVPKSWLMKA

Conjugate

Alternative Names

ABCC2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; DJS; MRP2; cMRP; ABC30; CMOAT; canalicular multispecific organic anion transporter 1; canalicular multidrug resistance protein; multidrug resistance-associated protein 2;

Entrez Gene ID

UniProt ID

Antigen Description

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia.

Pathway

ABC transporters; ABC-family proteins mediated transport; Bile secretion; Drug Induction of Bile Acid Pathway