Specifications
Immunogen
Purified recombinant fragment, corresponding to amino acids 481-674 of Human ABCB5, expressed in E. Coli.
Applications
Application Notes
WB: 1/500 - 1/2000; IHC-P: 1/200 - 1/1000; Flow Cyt: 1/200 - 1/400; ICC/IF: 1/200 - 1/1000;
Target
Alternative Names
ABCB5; ATP-binding cassette, sub-family B (MDR/TAP), member 5; ATP-binding cassette sub-family B member 5; ABCB5alpha; ABCB5beta; ATP binding cassette protein; EST422562; P glycoprotein ABCB5; ABCB5 P-gp; P-glycoprotein ABCB5; ATP-binding cassette protein
Product Background
Antigen Description
Plasma membrane transporter able to mediate efflux from cells of the rhodamine dye and of the therapeutic drug doxorubicin. Responsible for the resistance to doxorubicin of a subset of malignant melanomas.
Pathway
ABC transporters, organism-specific biosystem; ABC transporters, conserved biosystem; ABC-family proteins mediated transport, organism-specific biosystem; Transmembrane transport of small molecules, organism-specific biosystem.
Citations
Publication ()
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COA
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