Anti-PRDX5 monoclonal antibody, clone 7F6

Antibody Isotype

IgG1

Clone

7F6

Species Reactivity

Rat; Human; E. coli

Immunogen

Recombinant full length protein (Human).

Conjugate

Application Notes

WB: 1/1000; Flow Cyt: 1μg/10⁶ cells; IHC-P: 10 μg/ml; ICC/IF: 10 μg/ml;

Alternative Names

PRDX5; peroxiredoxin 5; peroxiredoxin-5, mitochondrial; ACR1; Alu co repressor 1; antioxidant enzyme B166; AOEB166; B166; liver tissue 2D page spot 71B; MGC117264; MGC142283; MGC142285; peroxisomal antioxidant enzyme; PLP; PMP20; PRDX6; PRXV; SBBI10; thio

Entrez Gene ID

UniProt ID

Antigen Description

Peroxiredoxin (Prx) is a growing peroxidase family whose mammalian members are involved in cell proliferation, differentiation, and apoptosis. There are many isoforms(about 50 proteins), known on the basis of amino acid sequence homology, particularly the amino-terminal region containing an active site cysteine residue. The thiol-specific antioxidant activity is distributed throughout all the kingdoms. Among them, mammalian Prx consists of 6 different members grouped into typical 2 Cys, atypical 2 Cys Prx, and 1 Cys Prx. Except PrxVI belonging to the 1 Cys Prx subgroup, the other five 2 Cys Prx isotypes share the thioredoxin dependent peroxidase(TPx) activity utilizing thioredoxin, thioredoxin reductase, and NADPH as a reducing system. Mammalian Prxs are 20–30 kilodaltons in molecular size and vary in subcellular localization:PrxI, II and VI in cytosol, PrxIII in mitochondria, PrxIV in ER and secretion, PrxV showing complicated distribution including peroxisome, mitochondria and cytosol.

Pathway

Peroxisome, organism-specific biosystem; Peroxisome, conserved biosystem; Selenium Pathway, organism-specific biosystem;