Alternative Names
Androsten; 4 Androsten 4 Chloro 3 17 Dione; 4-AT; 6-OXO; 4-etioallocholen-3 6 17-trione;
Concentration
Batch dependent - please inquire should you have specific requirements.
Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
Antigen Description
4-AT is a potent irreversible aromatase inhibitor that inhibits estrogen biosynthesis by permanently binding and inactivating aromatase in adipose and peripheral tissue. Aromatase is responsible for the conversion of testosterone to estradiol. Blocking aromatase causes the body to decrease in levels of estradiol, which then results in increase of LH and consequently, testosterone. Since testosterone has myotropic activity and estradiol does not, elevated testosterone levels increase muscle mass. However, there appear to be no human or animal studies testing the hypothesis that 4-AT will produce an anabolic effect.
Keywords
Androsten; 4 Androsten 4 Chloro 3 17 Dione; 4-AT; 6-OXO; 4-etioallocholen-3 6 17-trione;
Citations
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Adamczyk, M; Chen, YY; et al. A stereoselective synthesis of 1 alpha-(3'-carboxypropyl)-4-androsten-17 beta-ol-3-one: Preparation of immunoreagents for quantification of testosterone by fluorescence polarization immunoassay. TETRAHEDRON 53:12855-12866(1997).
CHRISTMAN, JK; NEHLS, S; et al. RELATIONSHIP BETWEEN ESTROGEN STRUCTURE AND CONFORMATIONAL-CHANGES IN ESTROGEN RECEPTOR/DNA COMPLEXES. JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 54:201-210(1995).