Rabbit Anti-Human ASXL1 (internal) Polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Human; Mouse

Immunogen

Synthetic peptide corresponding to internal residues of human ASXL1

Conjugate

Application Notes

IHC: 1:20-100

General Notes

This product (Catalog No. CABT-BL350) is a rabbit-derived polyclonal antibody raised against human ASXL1. This antibody exhibits cross-reactivity with ASXL1 from mouse. It has been affinity purified by Protein A. This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.
CABT-BL350 is suitable for use in IHC (1:20–1:100) application.
CABT-BL350 is supplied as a liquid formulation in pH7.4 PBS, 0.05% sodium azide, 40% Glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.

Alternative Names

MDS; BOPS

Entrez Gene ID

UniProt ID