Anti-ASB9 monoclonal antibody (DMABT-H13089)

Mouse anti-Human ASB9 monoclonal antibody for WB, IHC, IP, sELISA, ELISA Datasheet

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Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
2E9
Species Reactivity
Human
Immunogen
ASB9 (AAH01244,2a.a. ~ 252 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
ASB9; ankyrin repeat and SOCS box containing 9; ankyrin repeat and SOCS box protein 9; DKFZP564L0862; FLJ20636; MGC4954
Entrez Gene ID
UniProt ID

Product Background


Gene summary
ASB9 (Ankyrin Repeat And SOCS Box Containing 9) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is ASB7. This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.
Antigen Description
Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing and presentation, organism-specific biosystem; Immune System, organism-specific biosystem.

Citations


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References


Debrincat, MA; Zhang, JG; et al. The ankyrin repeat and SOCS box-containing protein Asb-9 targets creatine kinase B for degradation. FEBS JOURNAL 273:42-42(2006).
Fei, XW; Gu, X; et al. Crystal Structure of Human ASB9-2 and Substrate-Recognition of CKB. PROTEIN JOURNAL 31:275-284(2012).

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