Anti-ASB9 monoclonal antibody (DMABT-H13089)
Mouse anti-Human ASB9 monoclonal antibody for WB, IHC, IP, sELISA, ELISA
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ASB9 (AAH01244,2a.a. ~ 252 a.a) full-length recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
ASB9; ankyrin repeat and SOCS box containing 9; ankyrin repeat and SOCS box protein 9; DKFZP564L0862; FLJ20636; MGC4954
ASB9 (Ankyrin Repeat And SOCS Box Containing 9) is a Protein Coding gene. Among its related pathways are Immune System and Antigen processing- Ubiquitination and Proteasome degradation. An important paralog of this gene is ASB7. This gene encodes a member of the ankyrin repeat and suppressor of cytokine signaling (SOCS) box protein family. Members of this family can interact with the elongin B-C adapter complex via their SOCS box domain and further complex with the cullin and ring box proteins to form E3 ubiquitin ligase complexes. They may function to mediate the substrate-recognition of the E3 ubiquitin ligases. A transcribed pseudogene of this gene has been identified on chromosome 15. Multiple transcript variants encoding different isoforms have been found for this gene.
Substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A.
Adaptive Immune System, organism-specific biosystem; Antigen processing: Ubiquitination and Proteasome degradation, organism-specific biosystem; Class I MHC mediated antigen processing and presentation, organism-specific biosystem; Immune System, organism-specific biosystem.
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Debrincat, MA; Zhang, JG; et al. Ankyrin repeat and suppressors of cytokine signaling box protein Asb-9 targets creatine kinase B for degradation. JOURNAL OF BIOLOGICAL CHEMISTRY 282:4728-4737(2007).
Fei, XW; Zhang, Y; et al. Crystallization and preliminary X-ray analysis of the splice variant of human ankyrin repeat and suppressor of cytokine signaling box protein 9 (hASB9-2). PROTEIN AND PEPTIDE LETTERS 15:647-649(2008).
Custom Antibody Labeling
We offer labeled antibodies using our catalogue antibody products and a broad range of intensely fluorescent dyes and labels including HRP, biotin, ALP, Alexa Fluor® dyes, DyLight® Fluor dyes, R-phycoerythrin (R-PE), at scales from less than 100 μg up to 1 g of IgG antibody.