Product Overview
Blocking/Immunizing peptide for anti-APOBEC4 antibody
Tag/Conjugate
Unconjugated
Application Notes
For in vitro research use only. Not intended for any diagnostic or therapeutic purpose. Not for human or animal consumption.
Format
Lyophilized powder
Storage
Shipped at ambient temperature, store at -20°C.
Antigen Description
This gene encodes a member of the AID/APOBEC family of polynucleotide (deoxy)cytidine deaminases, which convert cytidine to uridine. Other AID/APOBEC family members are involved in mRNA editing, somatic hypermutation and recombination of immunoglobulin genes, and innate immunity to retroviral infection.
Function
hydrolase activity; hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines; metal ion binding; zinc ion binding;
Synonyms
APOBEC4; apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 4 (putative); C1orf169, chromosome 1 open reading frame 169; putative C->U-editing enzyme APOBEC-4; FLJ25691; MGC26594; RP1 127C7.4; putative C-> U-editing enzyme APOBEC-4; apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 4; C1orf169;
Citations
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Santa-Marta, M; da Silva, FA; et al. HIV-1 Vif protein blocks the cytidine deaminase activity of B-cell specific AID in E-coli by a similar mechanism of action. MOLECULAR IMMUNOLOGY 44:583-590(2007).
Lada, AG; Iyer, LM; et al. Incarnation of classical pro- and eukaryotic mechanisms of mutagenesis in hypermutagenesis and immunity of vertebrates. RUSSIAN JOURNAL OF GENETICS 43:1093-1107(2007).