This gene encodes a subunit of the heterotetrameric coat assembly protein complex 2 (AP2), which belongs to the adaptor complexes medium subunits family. The encoded protein is required for the activity of a vacuolar ATPase, which is responsible for proton pumping occurring in the acidification of endosomes and lysosomes. The encoded protein may also play an important role in regulating the intracellular trafficking and function of CTLA-4 protein. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function
lipid binding; protein binding; transporter activity
Synonyms
AP2M1; adaptor-related protein complex 2, mu 1 subunit; mu2; AP50; CLAPM1; AP-2 complex subunit mu; adaptin-mu2; AP-2 mu chain; AP-2 mu 2 chain; HA2 50 kDA subunit; clathrin coat adaptor protein AP50; clathrin coat assembly protein AP50; clathrin coat-associated protein AP50; adaptor protein complex AP-2 subunit mu; clathrin adaptor complex AP2, mu subunit; plasma membrane adaptor AP-2 50kDA protein; plasma membrane adaptor AP-2 50 kDa protein; adapter-related protein complex 2 mu subunit; adapter-related protein complex 2 subunit mu; clathrin assembly protein complex 2 medium chain; clathrin assembly protein complex 2 mu medium chain; clathrin-associated/assembly/adaptor protein, medium 1
Citations
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