FYB blocking peptide

Name: FYB blocking peptide
SKU: CDBP5014
Rating: 5 (1 reviews)

Synthetic FYB blocking peptide for IB

COA

SDS

Datasheet

Summary

Nature

Synthetic

Tag/Conjugate

Unconjugated

Format

Liquid

Concentration

200 μg/mL

Preservative

None

Storage

-20°C

Entrez Gene ID

2533

Antigen Description

The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]

Function

protein binding; protein complex binding; receptor binding

Synonyms

FYB; FYN binding protein; ADAP; PRO0823; SLAP-130; FYN-binding protein; p120/p130; FYB-120/130; FYN-T-binding protein; SLP-76-associated phosphoprotein; adhesion and degranulation-promoting adaptor protein

Citations

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Documents

pdf COA

pdf SDS

pdf Datasheet

QA & Reviews

Customer Reviews

References

DELAYED HEMOLYTIC TRANSFUSION REACTION CAUSED BY ANTI-FYB IN A SPLENECTOMIZED PATIENT

TRANSFUSION

Authors: BOYLAND, IP; MUFTI, GJ; HAMBLIN, TJ

Abstract

RED BLOOD CELL DUFFY ANTIGEN RECEPTOR FOR CHEMOKINES AND SUSCEPTIBILITY TO PLASMODIUM VIVAX INFECTION IN THAIS

SOUTHEAST ASIAN JOURNAL OF TROPICAL MEDICINE AND PUBLIC HEALTH

Authors: Pimpat, Yupawadee; Leelawat, Kawin; Lek-Uthai, Usa

Abstract

Plasmodium vivax is the most prevalent malaria infection in Thailand. P. vivax uses Duffy Antigen Receptor for Chemokines (DARC) or Duffy antigen (Fy) as a receptor for entry into reticulocytes. Polymorphism of DARC exon 2 gene (FYA/FYB) in 40 P. vivax-infected subjects were investigated using nested PCR of blood samples spotted on filter paper collected during August 2013 to November 2013 from various malaria clinics in Thailand. Distribution of DARC genotypes was FYA 62.5%, FYB 20% and FYAB 17.5%, consistent with that of Hardy-Weinberg equation. Mutation G17A was found in both FYA and FYB alleles, resulting in Gy148 and Asp48 of Fy(a) and Fy(b) antigen, respectively. Mean parasitemia among the three groups is not statistically different. To the best of our knowledge, this is the first such study in Thailand.