MSI1 Full Name
musashi RNA-binding protein 1
MSI1 Introduction
The RNA binding protein Musashi-1 (MSI1) plays an important role in various cellular functions, such as maintaining self-renewal and pluripotency of stem cells. MSI1 overexpression has been observed in several tumor tissues, including glioblastoma (GBM).This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA binding protein that is involved in post-transcriptional gene editing. It is a stem cell marker that controls the balance between self-renewal and terminal differentiation.
Figure. Structure of musashi RNA-binding protein 1.
Clinical Significance
The overexpression of MSI1 gene is associated with the malignancy and proliferation activity of gliomas and melanomas. Increased expression of MSI1 protein was observed in endometriosis, and siRNA mediated inhibition of MSI expression in endometrial cancer cells induces apoptosis and inhibits cell proliferation by affecting the Notch signaling pathway. MSI1 is highly expressed in neural progenitor cells and is essential for normal brain development. The mutations in these genes are the cause of autosomal recessive primary microcephaly. MSI1 also interacts with the Zika virus genome, which may explain why these cells are highly sensitive to Zika virus infection.
Musashi RNA-binding protein 1 (MSI1) is a phylogenetically conserved RNA-binding protein that plays a central role in post-transcriptional gene regulation, primarily influencing mRNA translation. It is a key molecular determinant of cell fate, best known for its function in promoting stem cell self-renewal and opposing differentiation, particularly in the central nervous system (CNS). First identified in Drosophila melanogaster, its mammalian homolog, MSI1, is crucial for neural development and has significant implications in various cancers, where its dysregulation is associated with malignancy and therapy resistance.
Alternate Names for MSI1
MSI1
musashi RNA-binding protein 1
RNA-binding protein Musashi homolog 1
musashi1
musashi-1
