Description
Squalene is a natural 30-carbon organic compound originally obtained for commercial purposes primarily from shark liver oil (hence its name), although plant sources (primarily vegetable oils) are now used as well, including amaranth seed, rice bran, wheat germ, and olives. It is also found in high concentrations in the stomach oil of birds in the order Procellariiformes. All plants and animals produce squalene as a biochemical intermediate, including humans. Squalene as an adjuvant is manufactured by Novartis Squalene is a hydrocarbon and a triterpene, and is a natural and vital part of the synthesis of all plant and animal sterols, including cholesterol, steroid hormones, and vitamin D in the human body. Squalene or squalane emulsions have been administered in human cancer vaccines, with mild side effects and evidence of efficacy, in terms of both immune responses and antitumor activity.
Binding capacity: 1-10 ug albumin. Note: Protein binding will vary with protein concentration, buffer and incubation conditions.
For in vitro research purpose only
Currently, squalene is used in: Anthrax vaccine adsorbed with Squalene adjuvant (Bacillus anthracis).
Formulation: C30H50
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