New antibody pairs of hMPV

Human metapneumovirus (hMPV) is a virus that usually causes symptoms similar to the common cold. It often causes upper respiratory infections, but it can sometimes cause lower respiratory infections like pneumonia, and asthma flare-ups or make chronic obstructive pulmonary disease (COPD) worse. hMPV infections are more common in the winter and early spring.

hMPV is an enveloped, non-segmented, negative-stranded virus that belongs to the subfamily Pneumovirinae. The hMPV genome (nearly 13 kb) contains eight genes that encode nine proteins, namely nucleoprotein (N), phosphoprotein (P), matrix protein (M), fusion protein (F), matrix-2 proteins (M2-1 and M2-2), small hydrophobic (SH) protein, glycoprotein (G), and large (L) polymerase protein. According to the genetic features of the F and G genes, hMPV strains prevalent worldwide could be classified into four genotypes (A1, A2, B1 and B2), and further divided into six lineages (A1, A2a, A2b, A2c, B1, and B2). Notably, co-prevalence of several sub-genotypes or sub-lineages of hMPV has been frequently reported in the areas under investigation, while the thorough relationship between the disease severity and hMPV genotype is yet unclear.

Fig. 1 Genomic organization of hMPV

Diagnosis of hMPV infection is commonly performed using molecular and serological techniques. Currently, there is no licensed vaccine available for the prevention of human Metapneumovirus infection and no antiviral treatment for the disease.

At Creative Diagnostics, we are committed to advancing research and diagnostics related to hMPV. Our dedicated research team has developed new antibody pairs and antigens targeting hMPV, specifically designed for the detection of the M and N proteins. These products are compatible with both chromatography and luminescence platforms, ensuring comprehensive solutions for your research needs.