Vaccine Grade

c-di-AMP

  • Product Name
  • c-di-AMP / Cyclic diadenylate monophosphate
  • Cat. No.
  • ADJU-017CL
  • Content
  • 1 mg of lyophilized c-di-AMP Vaccine grade adjuvant.
    10 ml sterile endotoxin-free physiological water (NaCl 0.9%)
  • Storage and Stability
  • c-di-AMP is shipped at room temperature and should be stored at -20°C. Lyophilized product is stable 1 year when properly stored.
    Upon resuspension, prepare aliquots of c-di-AMP and store at -20°C. Resuspended product is stable 6 months when properly stored. Avoid repeated freeze-thaw cycles.
  • Chemical Properties

  • Synonym: c-di-AMP diammonium salt
    CAS number: 54447-84-6
    formula: C20H30N12O12P2
    Molecular weight: 692.47
    Solubility: 2 mg/ml in physiological water
    Structure:
  • Description

  • Cyclic diadenylate monophosphate (c-di-AMP) is an intracellular signaling molecule produced by bacteria. Administration of c-di-AMP can induce a strong immune response in vitro and in vivo. It was recently found that this cyclic dinucleotide induces the production of cytokines, such as type I interferons, through the STING/TBK1/IRF3 pathway. Due to its immunostimulatory properties, this molecule has been investigated as a vaccine adjuvant. Mucosal delivery of c-di-AMP elicits a balanced Th1/Th2 profile and Th17 response2, which is crucial against intracellular pathogens. This adjuvant acts through the recruitment of monocytes and granulocytes, and the maturation of dendritic cells.
  • Preparation of Sterile Stock Solution (2 mg/ml)
  • Add 500 μl endotoxin-free physiological water to the 1 mg c-di-AMP vial to obtain a solution at 2 mg/ml.
    Mix the solution by pipetting up and down.
  • Working Concentration
  • 5-50 μg/mouse

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