Anti-ORC5 monoclonal antibody Made to order

Antibody Isotype

IgG

Species Reactivity

Human

Immunogen

A synthetic peptide of human ORC5L is used for rabbit immunization.

Conjugate

Alternative Names

ORC5; origin recognition complex, subunit 5; ORC5L; ORC5P; ORC5T; origin recognition complex subunit 5;

Entrez Gene ID

UniProt ID

Antigen Description

The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Alternatively spliced transcript variants encoding distinct isoforms have been described.

Pathway

Activation of ATR in response to replication stress; Activation of the pre-replicative complex; Assembly of the ORC complex at the origin of replication; Assembly of the pre-replicative complex; Association of licensing factors with the pre-replicative complex; CDC6 association with the ORC:origin complex; CDT1 association with the CDC6:ORC:origin complex; Cell Cycle; Cell Cycle Checkpoints; Cell Cycle, Mitotic;DNA Replication;