antigen sequence: GEASERDTRK LWRNIEPHLK KAMQTVYLRE ISSSQWEKLQ KDDTDPGQLK GLSAHTHVEL PYYSKFILIA A, corresponding to internal sequence amino acids 243-313 of Human ORC5L.
Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.
Pathway
Activation of ATR in response to replication stress; Assembly of the ORC complex at the origin of replication; Association of licensing factors with the pre-replicative complex; CDT1 association with the CDC6:ORC:origin complex
Citations
Publication ()
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