Anti-DKC1 (aa 192-221) polyclonal antibody

Antibody Isotype

IgG

Species Reactivity

Mouse; Human

Immunogen

Synthetic peptide within Human DKC1 aa 192-221 conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary. NP_001354.1.Database link: O60832

Conjugate

Application Notes

IHC-P: 1/50 - 1/100; WB: 1/1000; ICC/IF: 1/10 - 1/50.

Alternative Names

DKC1; dyskeratosis congenita 1, dyskerin; DKC; H/ACA ribonucleoprotein complex subunit 4; dyskerin; NAP57; NOLA4; XAP101; CBF5 homolog; cbf5p homolog; snoRNP protein DKC1; nucleolar protein NAP57; nucleolar protein family A member 4; nopp140-associated pr

Entrez Gene ID

UniProt ID

Antigen Description

Isoform 1: Required for ribosome biogenesis and telomere maintenance. Probable catalytic subunit of H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP) complex, which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Each rRNA can contain up to 100 pseudouridine (psi) residues, which may serve to stabilize the conformation of rRNAs. Also required for correct processing or intranuclear trafficking of TERC, the RNA component of the telomerase reverse transcriptase (TERT) holoenzyme.Isoform 3: Promotes cell to cell and cell to substratum adhesion, increases the cell proliferation rate and leads to cytokeratin hyper-expression (when overexpressed in HeLa cells).

Pathway

Cell Cycle; Chromosome Maintenance; Extension of Telomeres; H/ACA ribonucleoprotein complex; Regulation of Telomerase; Ribosome biogenesis in eukaryotes;