General Notes
This product (Catalog No. DPABH-22446) is a rabbit-derived polyclonal antibody raised against human DKC1, targeting the amino acid region 157–514 of the protein. It has been affinity purified by Protein A. This gene functions in two distinct complexes. It plays an active role in telomerase stabilization and maintenance, as well as recognition of snoRNAs containing H/ACA sequences which provides stability during biogenesis and assembly into H/ACA small nucleolar RNA ribonucleoproteins (snoRNPs). This gene is highly conserved and widely expressed, and may play additional roles in nucleo-cytoplasmic shuttling, DNA damage response, and cell adhesion. Mutations have been associated with X-linked dyskeratosis congenita. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014].
DPABH-22446 is suitable for use in Western blot (WB) (1:500–1:2,400), IHC (1:250–1:1,000), IF/ICC (1:50–1:500) applications.
DPABH-22446 is supplied as a liquid formulation in PBS with 0.02% sodium azide and 50% glycerol, pH 7.3. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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