Anti-XPC (aa 141-250) polyclonal antibody

Species Reactivity

Human

Immunogen

XPC (NP_004619, 141 a.a. ~ 250 a.a) partial recombinant protein with GST tag. The sequence is EPVLGDVRESTAFSRSLLPVKPVEIEIETPEQAKTRERSEKIKLEFETYLRRAMKRFNKG VHEDTHKVHLLCLLANGFYRNNICSQPDLHAIGLSIIPARFTRVLPRDVD

Conjugate

Alternative Names

XPC; xeroderma pigmentosum, complementation group C; XP3; RAD4; XPCC; DNA repair protein complementing XP-C cells; p125; mutant xeroderma pigmentosum group C;

Entrez Gene ID

UniProt ID

Antigen Description

This gene encodes a component of the nucleotide excision repair (NER) pathway. There are multiple components involved in the NER pathway, including Xeroderma pigmentosum (XP) A-G and V, Cockayne syndrome (CS) A and B, and trichothiodystrophy (TTD) group A, etc. This component, XPC, plays an important role in the early steps of global genome NER, especially in damage recognition, open complex formation, and repair protein complex formation. Mutations in this gene or some other NER components result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

Pathway

DNA Damage Recognition in GG-NER; Dual incision reaction in GG-NER; Global Genomic NER (GG-NER); Nucleotide excision repair