HIGH-RESOLUTION ALLELE FREQUENCIES FOR HLA-A, HLA-B, HLA-C, HLA-DQB1, HLA-DRB1 TYPING OF BONE MARROW DONORS RECRUITED BY THE NATIONAL BONE MARROW DONORS REGISTRY NAMED AFTER VASYA PEREVOSHCHIKOV, RUSSIA
HLA
Authors: Ananeva, Anastasiia V.; Leksina, Yana A.; Andryushkina, Anna V.; Gaifullina, Raushania F.; Shagimardanova, Elena I.
Abstract
Genetic diversity of HLA system in two populations from Tlaxcala, Mexico: Tlaxcala city and rural Tlaxcala
HUMAN IMMUNOLOGY
Authors: de los Angeles Pavon-Vargas, Maria; Crawford, Michael H.; Barquera, Rodrigo; Lopez-Gil, Concepcion; Arrieta-Bolanos, Esteban; Clayton, Stephen; Iraiz Hernandez-Zaragoza, Diana; Bravo-Acevedo, Alicia; del Rocio Ramos-de la Cruz, Flor; Mendez-Mani, Patricia; Zuniga, Joaquin; Yunis, Edmond J.; Bekker-Mendez, Carolina; Granados, Julio
Abstract
We studied HLA class I (HLA-A, -B) and class II (HLA-DRB1, -DQB1) alleles by PCR-SSP based typing in 1011 Mexicans from the state of Tlaxcala residing in the city of Tlaxcala (N = 181) and rural communities (N = 830), to obtain information regarding allelic and haplotypic frequencies. We find that the ten most frequent haplotypes in Tlaxcala are all of Native American origin. Admixture estimates revealed that the main genetic components are Native American (75.13 +/- 1.56% by ML; 69.24% based on of Native American haplotypes) and European (16.10 +/- 4.98% by ML; 19.74% of European haplotypes), with a less prominent African genetic component (8.78 +/- 4.09% by ML; 4.35% of African haplotypes).
COA
Publication 
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