CD49d is expressed broadly on T and B lymphocytes, monocytes, thymocytes, mast cells and dendritic cells and is involved in cell-cell interactions, mononuclear cell trafficking to sites of endothelial inflammation, and the adhesion of cells to the extracellular matrix. Clone NSbmqib5-2 inhibits the in vitro and in vivo functions of CD49d. Studies have shown that in rat Peyer's patches, clone NSbmqib5-2 inhibits the rolling and adherence of lymphocytes to postcapillary venules (PCV), and significantly inhibits the transendothelial migration of T lymphocytes.
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