General Notes
This product (Catalog No. DPABH-24783) is a rabbit-derived polyclonal antibody raised against human ATP2A2. This antibody exhibits cross-reactivity with ATP2A2 from mouse and rat. It has been affinity purified by Protein A. The ATP2A2 gene encodes the sarco/endoplasmic reticulum calcium-ATPase 2 (SERCA2), a magnesium-dependent enzyme that catalyzes the hydrolysis of ATP to transport calcium ions from the cytosol into the lumen of the sarcoplasmic reticulum (SR) or endoplasmic reticulum (ER), thereby regulating intracellular calcium levels essential for cellular signaling, muscle contraction, and relaxation. Located on chromosome 12q24.11, the gene spans approximately 70 kb with 21 exons and produces multiple isoforms through alternative splicing, including SERCA2a (predominant in cardiac and slow-twitch skeletal muscle) and SERCA2b (ubiquitously expressed in non-muscle tissues).
DPABH-24783 is suitable for use in WB 1 (500-1:2000), IHC 1 (50-1:200), IF/ICC 1 (100-1:500) applications.
DPABH-24783 is supplied as a liquid formulation in Phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. For long-term storage, keep at −20 °C. For short-term use, store at 2–8 °C. Avoid repeated freeze–thaw cycles to maintain antibody integrity and performance.
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