ARHGEF12 (NP_056128, 817 a.a. ~ 916 a.a) partial recombinant protein with GST tag. The sequence is VSREGILSPSELRKIFSNLEDILQLHIGLNEQMKAVRKRNETSVIDQIGEDLLTWFSGPG EEKLKHAAATFCSNQPFALEMIKSRQKKDSRFQTFVQDAE
Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli working through G protein-coupled receptors. The encoded protein may form a complex with G proteins and stimulate Rho-dependent signals. This protein has been observed to form a myeloid/lymphoid fusion partner in acute myeloid leukemia. Two transcript variants encoding different isoforms have been found for this gene.
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