What are cytokines?

Diagnostics

What are cytokines?

Cytokines are small secreted proteins released by cells have a specific effect on the interactions and communications between cells. The word cytokine is derived from the Greek kytos meaning ‘hollow’ or ‘vessel’ and kinein meaning ‘to move’ and was originally used to separate a group of immuno-regulatory proteins, such as interleukins, from other chemicals, known as growth factors, that modulated the proliferation and bioactivation of nonimmune cells. Cytokines aid cell to cell communication in immune responses and stimulate the movement of cells towards sites of inflammation, infection and trauma.

Cytokines

Types of Cytokines

While “cytokines” is an umbrella term that includes all kinds, there are more specific names given to cytokines. The major proteins/protein families that constitute the cytokine group of regulatory molecules as follows:

Interleukins (IL) Interferons (IFN)
Colony stimulation factors (CSF) Tumor necrosis factors (TNF)
Neurotrophins Ciliary neurotrophic factor (CNTF)
Glial cell-derived neurotrophic factor (GDNF) Epidermal growth factor (EGF)
Erythropoietin (EPO) Fibroblast growth factor (FGF)
Leukaemia inhibitory factor (LIF) Macrophage inflammatory proteins (MIP)
Platelet-derived growth factor (PDGF) Transforming growth factor (TGF)
Thrombopoietin (TPO)  

Most cytokines names are given based on cell types, biological activity and the structure. The term ‘cytokine’ was first introduced in the mid-1970s. It was applied to polypeptide growth factors controlling the differentiation and regulation of cells of the immune system. The interferons (IFNs) and interleukins (ILs) represented the major polypeptide families classified as cytokines at that time.

Interferons (IFNs) – Interferons (IFNs) are a group of signaling proteins made and released by host cells in response to the presence of several pathogens, such as viruses, bacteria, parasites, and also tumor cells.

IFNA1 IFNA2 IFNA3 IFNA4 IFNA5
IFNA6 IFNA7 IFNA8 IFNA10 IFNA11
IFNA13 IFNA14 IFNA16 IFNA17 IFNA21
IFNB1 IFNE IFNG IFNK IFNW1

Interleukins (ILs) – Interleukins are a group of cytokines that were first seen to be expressed by leukocytes and acting on other leukocytes.

IL1α IL1β IL2 IL3 IL4
IL5 IL6 IL7 IL8 IL9
IL10 IL11 IL12 IL13 IL15
IL16 IL17 IL18 IL19 IL20
IL21 IL22 IL23 IL24 IL25
IL26 IL27 IL29 IL31 IL32
IL33 IL34 IL37    

Cytokine names on the basis of producing cell types:

  1. Lymphokines – Cytokines such as interleukin-2 (IL-2) and interferon-γ (IFN-γ), produced by lymphocytes
  2. Monokines – Cytokines such as tumor necrosis factor-α (TNF-α) produced by monocytes.

Cytokine names on the basis of the specific biological activity by which the cytokine was first discovered:

  1. Tumor necrosis factor (TNF) – Cytokines exhibited cytotoxic effects on some cancer cell lines
  2. Colony stimulating factors (CSFs) – Cytokines promoted the growth in vitro of various leukocytes in clumps or colonies.

Cytokine names on a structural basis:

  1. “β-Trefoil” cytokines – include fibroblast growth factors, interleukin-1
  2. Chemokines – Interleukin-8, macrophage inflammatory proteins
  3. “Cysteine knot” cytokines- Nerve growth factor, transforming growth factors, platelet-derived growth factor
  4. EGF family
  5. Haematopoietins
  6. TNF family

The Functions of Cytokine

Cytokines have important roles in chemically induced tissue damage repair, in cancer development and progression, in the control of cell replication and apoptosis, and in the modulation of immune reactions such as sensitization. Each cytokine has a matching cell-surface receptor. Subsequent cascades of intracellular signaling then alter cell functions. Cytokines are often involved in several developmental processes during embryogenesis. Cytokines are crucial for fighting off infections and in other immune responses. Cytokines constitute the single most important group of biopharmaceutical substances. As coordinators of the immune and inflammatory response, manipulation of cytokine activity can have a major influence on the body’s response to a variety of medical conditions.

 

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