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Creative Diagnostics provides advanced AAV Antibodies and Titration ELISA kits for complex gene therapy and viral vector research applications. The AAV ELISA products from Creative Diagnostics provide specific detection of AAV capsid proteins and antibody responses across different serotypes while offering high sensitivity and wide measurement range for accurate quantification. The products use advanced assay optimization methods and rigorous validation procedures to generate dependable results for both laboratory and medical research settings.
The AAV Antibodies and Titration ELISA system achieves better signal detection through advanced chemistry and improved plate coating methods which result in stable measurements with low background interference and exact vector titer measurements. Creative Diagnostics provides research-grade ELISA solutions that scientists can use to track AAV vector stability and immune system reactions and vector strength with precision which speeds up gene delivery and vector development and biomanufacturing quality control advancements.
Creative Diagnostics' AAV Antibodies and Titration ELISA Products are essential tools across multiple research areas:
With high specificity, sensitivity, and validated performance, Creative Diagnostics' AAV Antibodies and Titration ELISA products deliver accurate, reproducible results for gene therapy development, AAV vector characterization, and immunogenicity studies.
Our kits undergo strict quality control procedures to achieve AAV Antibodies and Titration ELISA products from Creative Diagnostics deliver superior results for gene therapy research high specificity and ultra-sensitivity and consistent reproducibility while maintaining enhanced stability for both in vitro and in vivo applications. The AAV ELISA products enable researchers to measure AAV capsid proteins and detect anti-AAV antibodies and viral titers from different serotypes which helps them track vector potency and immune responses and serotype selection. The kits serve multiple research purposes by helping scientists evaluate vector characteristics and measure transduction efficiency and immune system reactions and AAV production quality. Our kits provide reliable experimental results through their multiple applications in research including vector characterization and transduction efficiency assessment and immune response evaluation and AAV manufacturing quality control. The products feature advanced assay chemistry and improved signal detection and validated controls which enhance their usability and experimental confidence and result in high-quality data across all studies. Our product advantages:
Ultra-Sensitive Detection
Enables accurate detection of low-titer AAV particles and trace amounts of antibodies, ensuring sensitivity and reliability.
High Specificity
Precisely identifies antibodies from different AAV serotypes, reducing background interference and improving signal-to-noise ratio.
Wide Dynamic Range
A wide concentration range is covered, enabling accurate quantification of low- to high-titer samples.
Optimized Assay Chemistry
Specialized plate coatings and signal enhancement technologies enhance signal strength and reproducibility.
Validated Controls and Standards
Standardized controls and quality control samples are provided to ensure batch-to-batch consistency and data reliability.
Compatibility with Multiple Serotypes
Supports detection of multiple serotypes, including AAV1–AAV9, for diverse research applications.
Reproducible and Robust
A rigorously validated process ensures experimental reproducibility and long-term stability.
High-Throughput Ready
Compatible with 96- and 384-well plates for high-throughput screening and production monitoring.
AAV Antibodies and Titration ELISA products from Creative Diagnostics serve as specific and sensitive tools for gene therapy research and viral vector characterization and immunogenicity studies. The ELISA kits from this company enable precise measurement of AAV capsid proteins and anti-AAV antibody detection and viral titer serotype selection through precise measurements. The validation process for each batch includes performance testing and stability assessment and assessment across different serotypes. The ELISA kits enable researchers to monitor vector potency and immune responses and reproducibility evaluation to achieve dependable results in laboratory and animal-based studies. The experimental accuracy and consistency of gene therapy studies improve through the combination of optimized assay chemistry and enhanced signal detection and validated controls. The products enable researchers to obtain reliable results during preclinical and clinical gene therapy studies.
| Cat. No. | Product Name | Description | |
| DMAB6351 | Anti-AAV1 (intact particle) monoclonal antibody, Clone BEL2b [Biotin] | Specifically detects AAV1 intact virus particles, both empty and full capsids. DMAB6351 recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. Not suitable for Immunoblotting. In immunofluorescence, a week cross-reactivity was observed with AAV6. No reaction with AAV type 2, 3, 4, 5. | Inquiry |
| DMAB6350 | Anti-AAV1 (intact particle) monoclonal antibody, Clone BEL2b | Specifically detects AAV1 intact virus particles, both empty and full capsids. DMAB6350 recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. Not suitable for Immunoblotting. In immunofluorescence and dot plot analysis, a week cross-reactivity was observed with AAV6 and AAV12. No reaction with other AAV types. | Inquiry |
| CABT-B9061 | Anti-AAV2 (intact particle) monoclonal antibody, clone B31 [Biotin] | Specifically detects intact virus particles, both empty and full capsids. With AAV2 and AAV3 CABT-B9061 recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. Not for WB. | Inquiry |
| CABT-B9062 | Anti-AAV2 (intact particle) monoclonal antibody, clone B31 | Specifically detects intact virus particles, both empty and full capsids. With AAV2 and AAV3 CABT-B9061 recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. Not for WB. | Inquiry |
| DMAB6346 | Anti-AAV2 Replicase monoclonal antibody, Clone A227.8 | Recognizes AAV replicase proteins Rep 78, Rep 68, Rep 52 and Rep 40 in AAV-infected cells. In Immunoblotting prominant reaction with Rep 78 and Rep 68, only faint reaction with Rep 52 and Rep 40. | Inquiry |
| DMAB6345 | Anti-AAV2 Replicase monoclonal antibody, Clone A304.10 | Recognizes AAV replicase proteins Rep 78, Rep 68, Rep 52 and Rep 40 in human AAV-2-infected cells. Cross-reactivity with AAV serotypes 1, 3, 4, 5, 6, 7, 8, 9 and 10 (4,11 and 12 were negative). A weak cross-reactivity is seen in some human cell lines. | Inquiry |
| DMAB6347 | Anti-AAV2 Replicase monoclonal antibody, Clone A77.4 | Recognizes AAV replicase proteins Rep78 and Rep52 in human AAV2-infected cells, no reaction with Rep68 and Rep40. Weak cross-reaction with AAV-serotype 3. | Inquiry |
| DMAB6348 | Anti-AAV2 VP1 monoclonal antibody, Clone B2 | DMAB6348 reacts with VP1 of AAV-2; weak cross-reaction with serotypes 1, 3, 4, 5, 6. In immunoprecipitation, an occasional reaction with a non-AAV-derived protein is found. | Inquiry |
| DMAB6349 | Anti-AAV2 VP1/VP2 monoclonal antibody, Clone B610 | Recognizes AAV-2 viral capsid proteins VP1 and VP2, which are highly enriched in the nucleus. Weak cross-reaction with serogroups 1, 3, and 6. | Inquiry |
| DPAB2423 | Anti-AAV2 VP1/VP2/VP3 polyclonal antibody | Reacts with VP1, VP2 and VP3. Raised against recombinant AAV-2 capsid proteins. | Inquiry |
| CABT-B9063 | Anti-AAV4 (intact particle) monoclonal antibody, clone BEL5 [Biotin] | Specifically detects AAV4 intact virus particles, both empty and full capsids. CABT-B9063 recognizes a conformational epitope of assembled capsids not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. | Inquiry |
| DMAB6352 | Anti-AAV4 (intact particle) monoclonal antibody, Clone BEL5 | Specifically detects AAV4 intact virus particles, both empty and full capsids. DMAB6352 recognizes a conformational epitope of assembled capsids not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. | Inquiry |
| DMAB6355 | Anti-AAV5 (intact particle) monoclonal antibody, Clone BEL6b [Biotin] | Specifically detects intact virus particles, both empty and full capsids. DMAB6355 recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. The antibody is not suitable for Immunoblotting. | Inquiry |
| DMAB6353 | Anti-AAV5 (intact particle) monoclonal antibody, Clone BEL6b | Specifically detects intact virus particles, both empty and full capsids. DMAB6353 recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. The antibody is not suitable for Immunoblotting. | Inquiry |
| DMAB6354 | Anti-AAV5 (intact particle) monoclonal antibody, Clone BEL6c | Specifically detects intact virus particles, both empty and full capsids. DMAB6353 recognizes a conformational epitope of assembled capsids, not present in denatured and native unassembled capsid proteins. No cross-reaction with other AAV serotypes. The antibody is not suitable for Immunoblotting. | Inquiry |
| DPAB2424 | Anti-AAV5 polyclonal antiserum | Raised against recombinant AAV5 capsid proteins. The antibody reacts with virus capsid proteins VP1, VP2, VP3 of AAV5; no cross-reaction with AAV types 1 - 4. | Inquiry |
| CABT-B9064 | Anti-AAV6 (intact particle) monoclonal antibody, clone BEL7 | Useful for analysis of the AAV assembly process. CABT-B9064 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Specific for AAV-6. No cross-reaction with AAV type 1, 2, 3, 4, 5, 7, 8, 9, 10, 11, and 12 was observed. Not for use in WB. | Inquiry |
| CABT-B9065 | Anti-AAV8 (intact particle) monoclonal antibody, clone BEL9 | For characterization of different stages of infection and very useful for analysis of the AAV assembly process. CABT-B9065 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Not for use in immunoblotting. | Inquiry |
| CABT-B9066 | Anti-AAV8/9 (intact particle) monoclonal antibody, clone BEL9/0 | For characterization of different stages of infection and very useful for analysis of the AAV assembly process. CABT-B9066 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. The antibody cannot be used for immunoblotting using denaturing conditions. | Inquiry |
| DPAB-AV01 | Anti-AAV9 (intact particles) monoclonal antibody, clone BEL0 | Useful for analysis of the AAV assembly process. DPAB-AV01 specifically reacts with intact adeno-associated virus particles, empty and full capsids. Recognizes a conformational epitope of assembled capsids. Not for use in WB. | Inquiry |
ELISA assays were used to detect anti-AAV antibodies in serum samples from different mouse models. OD450 values demonstrate differences in immune responses to different AAV serotypes, with error bars representing standard error (n = 3). This figure highlights the high specificity and sensitivity of the Creative Diagnostics ELISA kit.
Quantifying Anti-AAV Antibodies Using AAV Antibodies and Titration ELISA
Objective:
The biotech company which develops AAV-based gene therapy for hemophilia needs to assess immune reactions in mouse models before they can establish proper viral concentration standards for vector quality assessment.
Method:
Results:
The kit shows exceptional sensitivity because it detects both AAV antibodies and capsid proteins at very low concentrations which makes it suitable for research at early stages and for analyzing samples with low antibody titers.
The kit operates across various AAV serotypes which enables researchers to study multiple AAV vectors through single experiments.
The validation process for every batch includes control samples and standard materials which produces consistent results in every experiment.
The kit operates for both laboratory-based and animal-based research studies which enables researchers to monitor antibody responses and viral titers during animal experiments.
The kit provides specific results through its wide measurement range and enhanced signal detection capabilities. The kit provides validated controls and optimized chemistry to deliver reliable and consistent results.
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