Mouse anti-TRIB1 monoclonal antibody (CABT-B11664)

Mouse anti-Human TRIB1 monoclonal antibody for WB, sELISA, ELISA

Specifications


Host Species
Mouse
Antibody Isotype
IgG1
Clone
5B21
Species Reactivity
Human
Immunogen
TRIB1 (NP_079471, 91 a.a. ~ 192 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa.
Conjugate
Unconjugated

Target


Alternative Names
tribbles homolog 1 (Drosophila); G-protein-coupled receptor-induced gene 2 protein; C8FW; G-protein-coupled receptor induced protein; GIG2; G-protein-coupled receptor-induced protein 2
Entrez Gene ID
UniProt ID

Citations


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Custom Antibody Labeling


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References


Targeting pseudokinase TRIB3 brings about a new therapeutic option for acute promyelocytic leukemia

MOLECULAR & CELLULAR ONCOLOGY

Authors: Li, Ke; Wang, Feng; Hu, Zhuo-Wei

Pseudokinase tribbles (Trib) family, Trib1 and Trib2, but not Trib3, act as oncogene to drive acute leukemia by destabilizing the myeloid transcription factor CCAAT/enhancer-binding protein alpha (C/EBP alpha) and inhibiting myeloid differentiation. A recent study identifies pseudokinase TRIB3 as an important factor in acute promyelocytic leukemia (APL) progression and therapy resistance. Targeting TRIB3 may provide a novel therapeutic approach for APL.

Association analysis with lipid traits of 2 candidate genes (LRP12 and TRIB1) mapping to a SSC4 QTL for serum triglyceride concentration in pigs

JOURNAL OF ANIMAL SCIENCE

Authors: Melo, C.; Quintanilla, R.; Gallardo, D.; Zidi, A.; Jordana, J.; Diaz, I.; Pena, R. N.; Amills, M.

The performance of a genome scan for serum lipid traits at 45 and 190 d in 5 half-sib families of Duroc pigs allowed us to detect several pig chromosomal regions with significant effects on these phenotypes. In the current work, we aimed to refine the position of 1 chromosome 4 (SSC4) genome-wide significant QTL for serum triglyceride concentration at 190 d. Genotyping of 4 additional microsatellites allowed reduction of the 90% confidence interval of this QTL to the genomic interval between markers SW2409 and SW839. Sequencing experiments were performed to characterize the variability of 2 lipid-related genes, the lipoprotein receptor-related protein 12 (LRP12) and tribbles homolog 1 (TRIB1) loci, that map to this region. In this way, 2 (c. 771A > G and c. 1101A > G) and 1 (c.* 156_157del) polymorphisms were identified at the LRP12 coding region and TRIB13' untranslated region, respectively. Association analyses between LRP12 and TRIB1 genotypes did not reveal any significant effect on serum lipid concentrations, suggesting that variation of these two loci does not explain the segregation of the SSC4 QTL. However, highly significant associations were observed for gluteus medius saturated fatty acid content (LRP12 c. 1101A > G, P = 0.0006; TRIB1 c.* 156_157del, P = 0.0003). In the light of these and other findings, the potential involvement of LRP12 and TRIB1 in muscle lipid metabolism deserves to be further explored.

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