Triadimefon [KLH]

A series of novel anthranilic diamide derivatives containing pyridylpyrazole and iminodithiocarbamate or thiosemicarbazone motifs were synthesized via multi-step reactions. The structures of seven title compounds (methyl 2-(2-(3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamido)-5-chloro-3- methylbenzylidene)hydrazinecarbodithioate 7 and 3-bromo-N-(2-((2-substitutedcarbamothioylhydrazono)methyl)-4-chloro-6-methylphenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide 8a-8f) were confirmed by melting points, IR, H-1 NMR, C-13 NMR, and HRMS. The bioassays showed that some of the compounds exhibited modest insecticidal activities against oriental armyworm (Mythimna separata Walker), particularly, compound 8b (3-bromo-N-(4-chloro-2-methyl-6-((2-(methylcarbamothioyl)hydrazono)methyl)phenyl)-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxamide) held 100% and 30% larvicidal activity at the concentration of 25mg/L and 10mg/L, respectively. In addition, several compounds displayed favorable fungicidal activities against Alternaria solani Sorauer and Physalospora piricola at 50g/mL, and were comparable with the controls Chlorothalonil and Triadimefon. The results in this paper will provide important information for further research and development of sulfur-containing heterocyclic agrochemicals. [GRAPHICS] .

Single-drop microextraction (SDME) and gas chromatography microelectron capture detection (GC-m ECD) methods for the determination of four fungicides ( chlorothalonil, triadimefon, hexaconazole, and diniconazole) in water and wine were developed. The main parameters affecting the performance of SDME, such as selection of solvent, extraction time, organic drop volume, stirring rate, and salt concentration, were optimized. The relationship of the measured signal was a linear function (> 0.993) of concentration. Using chosen procedure in the concentration range of 0.01 to 50 mu g l(-1)(chlorothalonil 0.01 to 25 mu g l(-1)) the detection limits of the determination of studied pesticides in water were in the range of 0.006 - 0.01 mu g l(-1)(S/N = 3), the relative standard deviations (RSDs) < 8.6, and the enrichment factors > 56. The SDME-GC-mu ECD method was performed in natural water, wine, and the recoveries were acceptable.