Recombinant Pseudomonas aeruginosa exotoxin A (Non-toxic Mutant)
> 95%, by SDS-CGE under reducing conditions
Lyophilized in phosphat buffered saline (1X PBS), pH 7.5 Product Molecular Mass: 66.6 kDa
2-8°C short term, -20°C long term
Pseudomonas aeruginosa is a common bacterium that can cause disease in animals, including humans. It is found in soil, water, skin flora, and most man-made environments throughout the world. It thrives not only in normal atmospheres, but also in hypoxic atmospheres, and has, thus, colonized many natural and artificial environments. It uses a wide range of organic material for food; in animals, the versatility enables the organism to infect damaged tissues or those with reduced immunity. The symptoms of such infections are generalized inflammation and sepsis. If such colonizations occur in critical body organs, such as the lungs, the urinary tract, and kidneys, the results can be fatal. Because it thrives on most surfaces, this bacterium is also found on and in medical equipment, including catheters, causing cross-infections in hospitals and clinics. It is implicated in hot-tub rash. It is also able to decompose hydrocarbons and has been used to break down tarballs and oil from oil spills.
Pseudomonas aeruginosa is a common and often life-threatening pathogen of immune-compromised hosts. The organism produces several potential virulence factors, the most toxic of which is exotoxin A, a 613-residue cytocidal protein. Like diphtheria toxin, e
Pseudomonas aeruginosa; P. aeruginosa; Pseudomonas; Pseudomonadaceae; Pseudomonadales; Pseudomonas exotoxin; exotoxin A; exotoxin; Pseudomonas aeruginosa toxA; P. aeruginosa toxA